CAS# 5150-31-2 CAS NO.5150-31-2

An amine solvent modification of the Kostanecki-Robinson reaction Application to the synthesis of flavonols. Looker, James H.; McMechan, James H.…

An amine solvent modification of the Kostanecki-Robinson reaction Application to the synthesis of flavonols. Looker, James H.; McMechan, James H.; Mader, J. Woodson (Dep. Chem.Several substances like 5150-31-2 may be metioned in this study., Univ. Nebraska, Lincoln, Nebr., USA). J. Org. Chem., 43(12), 2344-7 (English) 1978. CODEN: JOCEAH. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The title modification of the Kostanecki-Robinson reaction for prepn. of flavonoids involves the use of anhyd. tertiary amines, usually NEt3 or N-ethylmorpholine, as solvent. Galangin 3-Me ether (I, R = R1, H), tamarixetin (I, R = MeO, R1 = OH), and flavone I (RR1 = OCH2O) were prepd. by the method. The 7-piperonylate of I (RR1 = OCH2O) was isolable when NaHCO3 was used as base in the isolation. Treating protocatechuic anhydride tetraacetate with w-methoxychloroacetophenone in NEt3 gave 2-methyl-3-methoxy-5,7-dihydroxychromone. .